Ming-Shiu Hung Selected Research

1- (2,4- dichlorophenyl)- N- (piperidin- 1- yl)- 4- ((pyrrolidine- 1- sulfonamido)methyl)- 5- (5- ((4- (trifluoromethyl)phenyl)ethynyl)thiophene- 2- yl)- 1H- pyrazole- 3- carboxamide

12/2013

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.

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Ming-Shiu Hung Research Topics

Disease

6	Neoplasms (Cancer) 02/2022 - 10/2015
2	Obesity 01/2019 - 01/2011
2	Weight Loss (Weight Reduction) 12/2013 - 09/2008
2	Type 2 Diabetes Mellitus (MODY) 01/2011 - 09/2006
1	Infections 01/2023
1	Virus Diseases (Viral Diseases) 01/2023
1	Hyperalgesia 11/2018
1	Body Weight (Weight, Body) 01/2016
1	Hyperglycemia 01/2011
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2011
1	Alcoholic Fatty Liver 01/2011
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2006

Drug/Important Bio-Agent (IBA)

4	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2020 - 01/2016
2	RimonabantIBA 01/2011 - 09/2008
1	fucoidanIBA 01/2023
1	FurinIBA 01/2023
1	Proteins (Proteins, Gene)FDA Link 01/2023
1	epacadostatIBA 01/2020
1	LeptinIBA 01/2019
1	GlucocorticoidsIBA 01/2019
1	gamma-Aminobutyric Acid (GABA)IBA 11/2018
1	OrexinsIBA 11/2018
1	EnzymesIBA 01/2018
1	Heme (Haem)IBA 01/2018
1	KynurenineIBA 01/2016
1	HydrazinesIBA 01/2016
1	Tryptophan (L-Tryptophan)FDA Link 01/2016
1	1- (2,4- dichlorophenyl)- N- (piperidin- 1- yl)- 4- ((pyrrolidine- 1- sulfonamido)methyl)- 5- (5- ((4- (trifluoromethyl)phenyl)ethynyl)thiophene- 2- yl)- 1H- pyrazole- 3- carboxamideIBA 12/2013
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2011
1	Glucose (Dextrose)FDA LinkGeneric 01/2011
1	SodiumIBA 01/2011
1	compound 18IBA 09/2008
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 09/2008
1	pyrazoleIBA 09/2008
1	Transcription Factors (Transcription Factor)IBA 09/2006

Therapy/Procedure

4	Immunotherapy 02/2022 - 01/2016
2	Oral Administration 01/2018 - 01/2016
1	Therapeutics 10/2015